One prescription—two powerful effects

• The power to calm inflammatory acne
  • Inflammation is an important aspect in the pathophysiology of acne¹
  • Both laboratory and clinical studies document the anti-inflammatory effects of minocycline¹
• The power to eradicate P acnes
  • Minocycline produced a significantly greater reduction in P acnes—even up to three weeks after discontinuation²
  • A decrease in P acnes can lead to a corresponding drop in pro-inflammatory cytokines resulting in reduced inflammation¹

Important Information
The most common adverse events associated with MINOCIN are nausea, vomiting, and diarrhea. Central nervous system adverse events including light-headedness, dizziness, or vertigo have been reported with minocycline therapy but are generally transient in nature. Other adverse events include tinnitus, headache, sedation, and skin pigmentation, particularly on the face and mucous membranes. MINOCIN is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines or to any of the components of the product formulation.
WARNING: MINOCIN Pellet-Filled Capsules, like other tetracycline-class antibiotics, can cause fetal harm when administered to a pregnant woman. The use of drugs of the tetracycline class during tooth development (last half of pregnancy, infancy, and childhood to the age of 8 years) may cause permanent discoloration of teeth (yellow-gray-brown). Concurrent use of tetracyclines may render oral contraceptives less effective.

Please see Prescribing Information, including WARNINGS, PRECAUTIONS, and ADVERSE REACTIONS sections.
References: 1. Sapadin AN, Fleischmajer R. Tetracyclines: nonantibiotic properties and their clinical implications. J Am Acad Dermatol. 2006;54(2):259-265. 2. Leyden JJ, McGinley KJ, Kligman AM: Tetracycline and minocycline treatment. Arch Dermatol. 1982;118:19-22.